What is meant by "treatment resistance" in cancer care?

Treatment resistance in cancer care refers to the phenomenon where cancer cells become unresponsive to therapies that were previously effective. This can occur due to various biological adaptations within the cancer cells, such as genetic mutations, alterations in cell signaling pathways, or changes in their microenvironment that enable them to survive despite the presence of the treatment.

Understanding treatment resistance is crucial because it has significant implications for patient management and outcomes. When a cancer no longer responds to a given treatment, oncologists must assess alternative therapies to effectively manage the disease. This concept is particularly important in the context of precision medicine, where targeted therapies are tailored based on specific characteristics of the tumor. Recognizing and addressing treatment resistance can lead to more effective care strategies and improve overall patient survival and quality of life.